RESPIRATION PHYSIOLOGY: PROBLEMS
Problem Session: Problem 7 Answer

PROBLEM SESSION ANSWERS: Problem 7

Step 1: Compute the inhaled oxygen concentration

PI-O2 = 0.21( PB - PH2O ) = 0.21 ( 200 - 47 ) = 0.21 x 153 = 32 mmHg

Step 2: Compute the alveolar PO2 using the alveolar air equation

PA-O2 = PI-O2 - PA-CO2 / R

Assuming PA-CO2 remains normal (as given) and assuming R = 0.8 gives

PA-O2 = 32 - 40/0.8 = 85 - 50 = -18 mmHg

So O2 would diffuse out of the blood in the pulmonary circulation.

Clearly, the person would not survive.

But, breathing pure oxygen at that altitude gives

Step 1: Compute the inhaled oxygen concentration

PI-O2 = 1.00( PB - PH2O ) = 1.00 ( 200 - 47 ) = 153 mmHg

Step 2: Compute the alveolar PO2 using the alveolar air equation for breathing pure oxygen:

PA-O2 = PI-O2 - PA-CO2

Assuming PA-CO2 remains normal(as given) gives

PA-O2 = 153 - 40 = 113 mmHg

This PA-O2 is even higher than when breathing air at sea level.

Clearly, the person could survive without difficulty breathing pure oxygen at this altitude.

Question: How long does the person have to put on the oxygen mask? Answer: about 20 seconds.